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DNA-RNA Hybrid Monoclonal Antibody [S9.6]
| 貨號 | 2112 | 售價（元） | 2800 |
| 規(guī)格 | 100ul | CAS號 |
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Product Name: |
DNA-RNA Hybrid Monoclonal Antibody [S9.6] |
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Cat No.: |
2112 |
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Clonality: |
Monoclonal |
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Species Reactivity: |
All Species |
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Tested Applications: |
ELISA, IP, IF, CHIP, Dot Blot |
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Recommended Dilution: |
IP: 1:50-500; IF: 1: 200 |
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Format: |
Liquid |
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Source: |
Mouse |
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Purification Method: |
Protein A/G Purified |
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Isotype: |
IgG2a |
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Conjugate: |
Unconjugated |
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Storage: |
Store at -20℃. Do not aliquot |
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Immunogen: |
ΦX174 bacteriophage-derived synthetic DNA/RNA |
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Full Name: |
DNA-RNA Hybrid |
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Background: |
The DNA-RNA hybrids are a natural occurrence within eukaryotic cells and their level are high at sites of high transcriptional activity. They are non-canonical nucleic acid structures with transcriptional regulatory functions. Their presence is reported to predispose a locus to chromosomal breakage. The S9.6 monoclonal antibody recognizes DNA-RNA hybrids (also known as R-loops) and does not bind to single or double stranded DNA. The antibody has high affinity for DNARNA hybrids but also binds RNA-RNA hybrids that are AU-rich. The specificity of the antibody appears to be determined by a combination of sequence and structural dependency since Rloop sequence affects binding affinity. |
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Category: |
Primary Ab |
Immunofluorescent analysis of ( 4% PFA) fixed HeLa cells
using DNA-RNA hybrid Mouse Monoclonal Antibody [S9.6]
at dilution of 1:500 and Alexa Fluor 647- conjugated
AffiniPure Goat Anti-Mouse IgG(H+L）
Chromatin immunoprecipitation analysis of HeLa cells genomic DNA(gDNA) using DNA-RNA hybrid Mouse Monoclonal Antibody [S9.6] at dilution of 1:200